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KMID : 0367320050160010054
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Journal of the Korean Academy of Child and Adolescent Psychiatry
2005 Volume.16 No. 1 p.54 ~ p.62
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A FAMILY-BASED AND CASE-CONTROL ASSOCIATION STUDY OF THE DOPAMINE BETA HYDROXYLASE GENE POLYMORPHISM IN ATTENTION DEFICIT HYPERACTIVITY DISORDER
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Park Tae-Won
Kim Bung-Nyun
Lim Myung-Ho
Yoo Hee-Jeong
Kang Dae-Hee
Cho Soo-Churl
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Abstract
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Objective: Attention deficit hyperactivity disorder (ADHD) is the most common childhood psychiatric disorder, affecting 3-5% of school age children. Although the biological basis of ADHD is unknown, family studies provide strong evidence that ADHD has a genetic basis. Recent genetic studies have suggested associations between ADHD and Taq I polymorphism of dopamine beta hydroxylase gene(DBH) . The aim of this study is to test the association between ADHD and Taq I polymorphism of DBH in Korean population.
Method: We processed DNA extraction and genotyping for 106 korean children with ADHD and their parents. Genotyping was additionally performed for 212 age and gender matched normal controls. Case-control association study was applied. And we tested the association using the transmission disequilibrium test (TDT) and haplotype-based haplotype relative risk test (HHRR).
Results: There were no statistical differences of genotype distributions between cases and controls. However, we did observe preferential transmission of allele Al of DBH Taq T polymorphism in ADHD.
Conclusion: On the whole, our results lend credence to the notion that the relationship between ADHD and DBH is complex. The number of cases and informative transmissions were small, therefore it would be premature to make any conclusions from our study concerning the role of DBH in ADHD. Further work is needed to support these findings.
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KEYWORD
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Attention deficit hyperactivity disorder(ADHD), Polymorphism, Dopamine beta hydroxylase(DBH)
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